Metal–Organic Frameworks in Microfluidics Enable Fast Encapsulation/Extraction of DNA for Automated and Integrated Data Storage

DNA as an exceptional data storage medium offers high
information
density. However, DNA storage requires specialized equipment and tightly
controlled environments for storage. Fast encapsulation within minutes
for enhanced DNA stability to do away with specialized equipment and
fast DNA extraction remain a challenge. Here, we report a DNA microlibrary
that can be encapsulated by metal–organic frameworks (MOFs)
within 10 min and extracted (5 min) in a single microfluidic chip
for automated and integrated DNA-based data storage. The DNA microlibrary@MOFs
enhances the stability of data-encoded DNA against harsh environments.
The encoded information can be read out perfectly after accelerated
aging, equivalent to being readable after 10 years of storage at 25
°C, 50% relative humidity, and 10 000 lx sunlight radiation.
Moreover, the library enables fast retrieval of target data via flow
cytometry and can be reproduced after each access.