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Desymmetrization of Cyclic Anhydrides Using Dihydroxy Compounds: Selective Synthesis of Macrocyclic Tetralactones

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https://figshare.com/articles/dataset/Desymmetrization_of_Cyclic_Anhydrides_Using_Dihydroxy_Compounds_Selective_Synthesis_of_Macrocyclic_Tetralactones/3225544
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The desymmetrization of cyclic anhydrides is carried out using dihydroxy compounds. A mild route to synthesize fused saturated/unsaturated macrocyclic tetralactones with different ring sizes (20−34) having a wide variety of spacers is described. The structure is confirmed by the representative single-crystal X-ray analysis. The multiple reduction of unsaturated macrocyclic tetralactones is also illustrated. This method is mild, selective, and efficient and achieves high yield.
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