GNPS - MaHPIC Experiment 03: Lipidomics from Macaca mulatta infected with Plasmodium coatneyi Hackeri strain to produce and integrate clinical, hematological, parasitological, and omics measures of acute, recrudescent, and chronic infections.

Malaria-naive male rhesus macaques (Macaca mulatta),
approximately four years of age, were inoculated intravenously with salivary
gland sporozoites produced and isolated at the Centers for Disease Control and
Prevention from multiple Anopheles species (An. dirus, An. gambiae,
and An. stephensi) and then profiled for clinical, hematological,
parasitological, immunological, functional genomic, lipidomic, proteomic, and
metabolomic measurements. The experiment was designed for 100 days, and pre-
and post-100 day periods to prepare subjects and administer curative treatments
respectively. The anti-malarial drug artemether was subcuratively administered
to all subjects at the initial peak of infection, one out of the five macaques
received four additional subcurative treatments for subsequent recrudescence
peaks.  The experimental infection in one subject was ineffective but the
macaque was followed-up for the same period of 100 days. The different clinical
phases of the infection were clinically determined for each subject. 
Blood-stage curative doses of artemether were administered to all subjects at
the end of the study.  Capillary blood samples were collected daily for
the measurement of CBCs, reticulocytes, and parasitemias. Capillary blood
samples were collected every other day to obtain plasma for metabolomic
analysis. Venous blood and bone marrow samples were collected at seven time
points for functional genomic, proteomic, lipidomic, and immunological
analyses. Within the MaHPIC, this project is known as 'Experiment 03'.

This dataset was produced by: The MaHPIC Consortium, Monica Cabrera-Mora, Jeremy D. DeBarry, Mary R. Galinski, Jay C. Humphrey, Ebru Karpuzoglu, Jessica C. Kissinger, Regina Joice Cordy, Esmeralda VS Meyer, Alberto Moreno, Vishal Nayak, Mustafa V. Nural, Daniel S. Ory, Suman B Pakala, and Xuntian Jiang. The experimental design and protocols for this study were approved by the Emory University Institutional Animal Care and Use Committee (IACUC).

For more information on the MaHPIC, please visit http://www.systemsbiology.emory.edu/.
To access other publicly available results from 'E03' and other MaHPIC Experiments, including clinical results (specifics on drugs administered, diet, and veterinary interventions), and other omics, visit http://plasmodb.org/plasmo/mahpic.jsp. This page will be updated as datasets are released to the public."