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NANOS2-binding regulates mRNA half-life and key spermatogonial stem cell self-renewal pathways

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干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=70f27fc596e04fc4f2b196c942ea7786
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We have identified NANOS2 bound targets transcriptome wide by employing CRAC and RNA-seq in mouse SSCs. We have determined the average mRNA half-life in SSCs by SLAM-seq. By comparing CRAC and SLAM-seq datasets, we have demonstrated that NANOS2 binding reduces mRNA stability in SSCs.
提供机构:
Queen Mary University London
创建时间:
2022-02-20
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