Whole-genome methylation sequencing reveals that SARS-CoV-2-induced epigenetic dysregulation remains one year after hospital discharge

We compared paired longitudinal samples from patients admitted for SARS-CoV-2 infection with their methylome obtained one year after hospital discharge, and with methylome profiles from age- and sex-matched healthy individuals who were never diagnosed with COVID-19. DMRs that do not return to baseline after one year are attractive targets to further investigate the epigenetic underpinning of persistently dysregulated immune and inflammatory profiles evoked by COVID-19 infection.