Atropisomeric Properties of the Dibenzo[b,d]azepin-6-one Nucleus

Dibenzo[b,d]azepin-6-ones (2a,b) were separated by chiral HPLC into the aR- and aS-atropisomers with high stereochemical stability, and methylation at C7 of 2a stereoselectively gave the (aR*,7R*) isomer (4a), which converted to the thermodynamically stable (aS*,7R*) atropisomer (5a) after heating.

二苯并[b,d]氮杂环庚-6-酮(2a,b)通过手性高效液相色谱法分离得到具有高立体化学稳定性的aR-和aS-阿托异构体，对2a的C7位进行选择性甲基化可获得(aR*,7R*)异构体(4a)，该异构体在加热后转化为热力学稳定的(aS*,7R*)阿托异构体(5a)。