Distributed control circuits across a brain-and-cord connectome

This repository contains the data associated with the manuscript “Distributed control circuits across a brain-and-cord connectome”. The dataset represents a synapse-resolution reconstruction and annotation of the adult female Drosophila melanogaster central nervous system, spanning both the brain and ventral nerve cord (VNC). Included in this repository are: * Cell annotations: including soma locations, proofreading status, cell type assignments and information about cell functions * Neurotransmitter predictions * Connectivity matrices * NBLAST similarity results between BANC neurons and neurons from existing connectomes including HemiBrain, FAFB (Full Adult Fly Brain), FANC (Female Adult Nerve Cord), and MANC (Male Adult Nerve Cord), as well as comparisons within BANC * L2 skeletal representations of neurons, generated using the pcg_skel tool * colorMIP images of all BANC neurons * Influence scores from defined source neuron groups (e.g., sensory), computed using the linear dynamical model described in the manuscript * Aligned metadata linking data elements to the cell types and analyses presented in the BANC manuscript The downloadable data is based on CAVE materialization 626, snapshotted on July 21, 2025, and provides a stable reference for the analyses and figures in the preprint. A brief guide on navigating our data: Neurons in our dataset were tracked using the CAVE (Connectome Annotation Versioning Engine) system. Neurons have a 'root_id', a 64-bit integer that identifies a unique neuron state, which changes each time a neuron is 'edited'. Each identified neuron in materialization 626 has a unique 'root_id'. To track 'neurons', we have tracked 'stable' points within neurons ('position') and the underlying fixed segmentation ID for an atomic set of segmented voxels associated with that position, i.e. a 'supervoxel_id'. A 'position' (a voxel) can give you a 'supervoxel_id' (a small, uneditable collection of voxels) and a 'supervoxel_id' can give you a 'root_id' (a large editable collection of supervoxels). Synaptic links also have their own 'id'. Columns appended with 'pt_' indicate that the given information was tracked from a point position that a user added to a CAVE table. Researchers are encouraged to use these data in conjunction with the online resources on the BANC portal (https://banc.community) and FlyWire Codex (https://codex.flywire.ai/banc) for further annotation, exploration, and integration with community datasets. While this dataverse is a stable snapshot of the data we used in our preprint, FlyWire Codex will serve more up-to-date and corrected data. The BANC is a live project.