Stimulation of Stem Cell Factor in Retinal Degeneration

Degenerative retinal disease is the leading cause of vision loss, while a limited number of effective treatments are currently being explored. Here we demonstrated that stimulation of SCF compromised the NMDA-induced experimental retinal injury. Mechanistically, this effect was mediated by inhibiting the activation of microglia, and providing of a suitable microenvironment for tissue regeneration. These finding suggested that applying SCF would be an effective strategy for retina therapy.