NEUROPROTECTIVE EFFECT OF POLYHERBAL FAST DISSOLVING TABLET OF CURCUMIN, QUERCETIN AND RUTIN AGAINST STREPTOZOTOCIN INDUCED DIABETIC NEUROPATHY IN RODANTS

Purpose: In the Current study we conducted the neuroprotective effect of the Polyherbal combination of curcumin, quercetin and rutin in Streptozotocin-induced Diabetic neuropathy in diabetic rat.

Method: In the 12 week study, two different formulations of polyherbal fast dissolving tablets were administered to diabetic rats. Neuropathic pain was assessed in diabetic rats with numerous aching trials and these tests were carried out for the consideration of thermal, mechanical, cold and hot hyperalgesia and nerve co-ordination. At the end of this study, trial animals were sacrificed and examined for biochemical parameters.

Result: Animals treated with poly herbal fast dissolving tablet to attenuate hyperglycaemia induced mechanical, thermal hyperalgesia and cold allodynia and improved the biochemical parameters in a dose-dependent manner.

Conclusion From this it was conclude that polyherbal fast dissolving tablet of curcumin, quercetin and rutin significantly exhibits the antidiabetic, antioxidant and neuroprotective activities against streptozotocin-induced diabetic neuropathy in rats.