Construction of a Regulatory Element Map in Sheep

Comprehensive functional genome annotation is critical for understanding the molecular mechanisms underlying complex traits and diseases. Although some tissues in sheep, an important domesticated animal, have been functionally annotated, there is still a lack of systematic functional genome annotation for reproductive tissues. In this study, we integrated 60 transcriptomic and epigenomic datasets from five reproductive tissues. Through integrative multi-omics analysis, we constructed the first regulatory element map for sheep reproductive tissues and explored the roles of regulatory elements in sheep reproductive traits and diseases.