Multivariate analysis of <i>thymidylate synthase</i> polymorphisms and clinical response to methotrexate.

P value<0.05 is considered to be of statistical significance (highlighted in bold). Adjusted variables include: 1) patient-related variables (age, gender and smoking); 2) disease-related variables (diagnosis age and disease duration); and 3) treatment-related variables (folic acid supplementation, corticosteroids, non-steroidal anti-inflammatories, other concomitant disease-modifying antirheumatic drugs and methotrexate administration characteristics - dose, treatment duration and administration route). Genetic variables include: TYMS genotypes and TYMS haplotypes. bp: base pairs; C: cytosine; del: deletion; G: guanine; OR: odds ratio; R: repeat; TSER: TYMS enhancer region; TYMS: thymidylate synthase (gene); VNTR: variable number tandem repeat. Multivariate analysis of thymidylate synthase polymorphisms and clinical response to methotrexate.