IBS colon epithelium transcriptome from water avoidance stressed BALB/c & C57BL/6J mice
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https://www.ncbi.nlm.nih.gov/sra/SRP352657
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资源简介：
Glucocorticoids (GCs) are major hormone signals shared by stress and circadian, GCs dysregulation by stress leads to circadian misalignment and impaired gut-brain axis causing IBS. GR maintains intestinal epithelium homeostasis and barrier function via transcriptional regulation of target genes including core circadian gene Nr1d1 and circadian controlled genes. We profiled BALB/c & C57BL/6J colon epithelium transcriptome in response to water avoidance stress. BALB/c strain-specific WAS decreased Nr1d1 and multiple differentially expressed genes (DEGs) relevant to circadian and IBS were detected.
创建时间：
2023-07-06
