GRASPing experience-dependent protein expression signatures enriched for hippocampal engram cell synapses
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To investigate how learning shapes the molecular composition of synapses we enriched specific synaptic subpopulations from the hippocampus using fluorescence-based tagging and flow-cytometric synapse sorting. Sorted synaptosomes were analysed using label-free quantitative mass spectrometry–based proteomics. Comparative profiling across different behavioral experiences revealed distinct protein signatures associated with synaptic structure and function.
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Zenodo创建时间：
2025-10-29
