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A Dual-Catalysis/Anion-Binding Approach to the Kinetic Resolution of Allylic Amines

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https://figshare.com/articles/dataset/A_Dual_Catalysis_Anion_Binding_Approach_to_the_Kinetic_Resolution_of_Allylic_Amines/2656135
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A dual-catalysis approach enables the small-molecule catalyzed kinetic resolution of allylic amines by acylation. By employing 2 mol % of each 4-(pyrrolidino)pyridine (PPY) and a readily available chiral hydrogen-bonding cocatalyst, the first nonenzymatic kinetic resolution of allylic amines was accomplished with s factors of up to 20.
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2011-05-06
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