Adult-born granule cells modulate CA2 network activity during retrieval of developmental memories of the mother

Adult-born granule cells (abGCs) project to the CA2 region of the hippocampus, but no previous studies have assigned a behavioral function to this circuit. Here we show that abGC input to the CA2 is necessary for the retrieval of remote social memories. We also found that abGCs are necessary for differential CA2 network activity, including theta-gamma coupling and sharp wave-ripples, in response to novel versus familiar social stimuli., , , # Electrophysiology recordings (CA2):

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The Electrophysiology.zip file contains raw data obtained from wireless hippocampal recordings in freely behaving mice. In one experiment, Nestin-cre and Nestin-cre:Gi mice were recorded at baseline and during exposure to a social stimulus. In another experiment, Nestin-cre and Nestin-cre:Gi mice were recorded at baseline and during exposure to a non-social stimulus. For both experiments, animals were recorded after vehicle or CNO administration. Drug administration was counterbalanced, as was the order of stimulus presentation. For the social stimulus experiment, recordings occurred when Gi-DREADD+ adult-born neurons were 4-6 weeks old and once again when the cohort of neurons was 10-12 weeks old. For the non-social stimulus experiment, recordings occurred when Gi-DREADD+ adult-born neurons were 4-6 weeks old only. Data filtering and normalization methods, as well as Python scripts used for analysis, are provided in the manuscript. Files were...