Paired differential gene expression and splicing analyses results of 199 baseline vs. case comparisons across 100 datasets

This dataset contains results from paired differential expression and differential splicing analyses as well as gene-set over-representation analysis results for 199 baseline vs. case comparisons across 100 randomly curated datasets with accompanying metadata (article).All results were computed using the R package pairedGSEA, which utilized DESeq2 (Love et al., 2014), DEXSeq (Anders et al., 2012), and fgsea (Korotkevich et al., 2019).See limma results here: https://doi.org/10.5281/zenodo.8162214Each .RDS file contains a list with four objects: A 'metadata' object with the metadata of the respective raw data, a 'genes' object with gene-level differential splicing and expression results, a 'gene_set' object with over-representation results, and 'experiment' with the experiment title.The filenames follow this pattern: "[dataset ID]_[GEO accession number]_[Manually assigned comparison title].RDS".All datasets were obtained from a local copy of the ARCHS4 v11 database of transcript counts (Lachmann et al., 2018).