Whole genome sequencing of caspofungin adaptors derived from homozygous deletion strains of PKC and calcineurin pathways in Candida albicasn. Whole genome sequencing of caspofungin adaptors derived from homozygous deletion strains of PKC and calcineurin pathways in Candida albicasn

In Candida albicans, PKC pathway genes MKK2 and MKC1, as well as calcineurin pathway genes CMP1 and CNB1 were deleted. The deletion strains were used to obtain caspofungin adaptors which gained tolerance to caspofungin. These adaptors as well as the wild type strain SC5314 were sequenced.