Axonal transport of NGF:Trk complexes

Of the internalized NGF:TRK complexes, many undergo recycling and/or proteolysis. Only a small fraction is retrogradely transported. Vesicles containing neurotrophin, activated receptors and downstream kinases are transported through axons by the action of dynein, which produces a force towards the end of microtubules.

在内部化的NGF:TRK复合物中，众多复合物经历回收和/或蛋白水解。仅有极小部分逆向运输。神经生长因子、激活的受体及下游激酶所含的囊泡，在动力蛋白的作用下，通过轴突运输，动力蛋白产生一种推动力，作用于微管末端的区域。