X-ray structure of BACE1 in complex with a bicyclic isoxazoline carboxamide as the P3 ligand
收藏Protein Data Bank Japan2024-10-23 更新2026-03-21 收录
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X-ray structure of BACE1 in complex with a bicyclic isoxazoline carboxamide as the P3 ligand Descriptor: (3R,3aR,6aS)-N-[(4R,7S,8S,10R,13S)-8-hydroxy-10,17-dimethyl-7-(2-methylpropyl)-5,11,14-trioxo-13-(propan-2-yl)-2-thia-6,12,15-triazaoctadecan-4-yl]hexahydrofuro[3,2-d][1,2]oxazole-3-carboxamide, Beta-secretase 1, GLYCEROL, ... Authors: Mesecar, A.D, Lendy, E.K. Deposit date: 2018-05-19 Release date: 2018-07-25 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand. Bioorg. Med. Chem. Lett., 28, 2018
创建时间：
2018-05-19
