Genetically predicted mood disorders increased risk of Cisplatin-induced hearing loss in childhood cancer: Evidence from a Bidirectional Mendelian randomization study

It remains unclear whether the mood swings in children with cancer are causally related to the increased risk of hearing loss caused by cisplatin.The first investigation into the interaction between mood swings and cisplatin-induced hearing loss.It is a two-sample Mendelian randomization analysis. Mendelian randomization (MR) emerges as a valuable approach, employing genetic variations as instrumental variables to infer causal links between exposure factors and outcomes.