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Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.

ChEBI2008-09-06 更新2026-07-21 收录

急性早幼粒细胞白血病机制

染色质与基因调控及基因组稳定性

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-12641 数据链接链接失效反馈

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资源简介：

Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.

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创建时间：

2008-09-06

急性早幼粒细胞白血病机制

细胞恶性转化

PML/RARA is the oncoprotein driving acute promyelocytic leukemia (APL). It suppresses genes expression by recruitment of a number of transcriptional repressors, resulting in differentiation block and

Figshare2016-01-15 更新40

Arsenic-induced PML targeting onto nuclear bodies: Implications for the treatment of acute promyelocytic leukemia

急性早幼粒细胞白血病机制

砷剂靶向治疗

Acute promyelocytic leukemia (APL) is associated with the t(15;17) translocation, which generates a PML/RARα fusion protein between PML, a growth suppressor localized on nuclear matrix-associated bodi

PubMed Central1997-04-15 更新20

Transcription profiling of human normal bone marrow CD34+ cells, promyelocytes, and neutrophils and PR9 cell line PML-RARA induction time series

造血细胞转录组

急性早幼粒细胞白血病机制

Transcription profiling of human normal bone marrow CD34+ cells, promyelocytes, and neutrophils and PR9 cell line PML-RARA induction time series

ChEBI2008-10-26 更新10

Expression and function of PML-RARA in the multipotent hematopoietic progenitor cells of Ctsg-PML-RARA mice

急性早幼粒细胞白血病机制

造血干细胞功能

Because PML-RARA-positive acute promyelocytic leukemia (APL) is a morphologically differentiated leukemia, much speculation has been made about whether its leukemic cell of origin might be committed m

NIAID Data Ecosystem30

Disease specific epigenetic deregulation of enhancers, transposons and polycomb targets in acute promyelocytic leukemia

急性早幼粒细胞白血病遗传学

染色质与基因调控及基因组稳定性

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML), characterized by a fusion between the PML and RARA genes and by a block in the myeloid maturation at the promyelocytic

NIAID Data Ecosystem10

Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.

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