Differentially expressed proteins identified by MALDI-TOF-TOF MSMS.

All the listed proteins showed a statistical difference of spot volume ratio between the control/BTTR-wt and control/BTTR-L55P with an ANOVA pa)Gene code as in the yeast genome database (www.yeastgenome.org).b)CM – carbohydrate metabolism; AM – amino acid metabolism; NM – nucleotide metabolism; EM – energy metabolism; LM – lipid metabolism; U – unknown; CRH – cell redox homeostasis; T – translation; TP – transport; PFD – protein folding and degradation.c)Accession code of the uniprot database (www.uniprot.org).d)Spot number on the master gel (see fig. 1A).e)Summary of the protein identification results. The protein and the peptide score as given by the GPS Explorer software (Applied Biosystems). The number of peptides with MSMS data is also given.