PTEN Deficiency Promotes Pathological Vascular Remodeling of Human Coronary Arteries

We used Affymetrix microarrays to detail the global program of gene expression changes between PTEN deficient and wild type smooth muscle cells. We identified distinct classes of up- and down-regulated genes during this process.本研究采用Affymetrix基因芯片（Affymetrix microarrays），详细解析了PTEN缺陷型与野生型平滑肌细胞之间的全基因表达变化全局程序，并在此过程中鉴定得到了多类不同的上调与下调基因。