National Cancer Institute Familial Burkitt Lymphoma in Shirati (FBiS). National Cancer Institute Familial Burkitt Lymphoma in Shirati (FBiS)

In 1980, Dr. Glen Brubaker and colleagues reported 5 familial cases of Burkitt Lymphoma (BL) in Shirati in Tanzania and began collecting cryopreserved lymphocytes from affected and non-affected family members to study the potential genetic basis of familial BL occurring in the malaria belt in Africa. This area is settled by the Luo tribe (85% of the population), a Nilotic group, which migrated from the Sudan regions of Africa, and the Kuria, a mixture of Nilotic and Bantu tribes. Control samples were obtained from members of similar families from the same location but who did not have BL cases reported in their family were also sampled. The family study collected data from 320 individuals in 12 families with two or more BL cases (familial BL families, n=63), 36 families with single BL... (for more see dbGaP study page.)