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Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist PT2385

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Protein Data Bank Japan2023-10-11 更新2026-03-21 收录
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Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist PT2385 Descriptor: 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 Authors: Wu, D, Su, X, Lu, J, Li, S, Hood, B, Vasile, S, Potluri, N, Diao, X, Kim, Y, Khorasanizadeh, S, Rastinejad, F. Deposit date: 2018-07-15 Release date: 2019-02-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3 Å) Cite: Bidirectional modulation of HIF-2 activity through chemical ligands. Nat. Chem. Biol., 15, 2019
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2018-07-15
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