Orthogonal Selectivity in C–H Olefination: Synthesis of Branched Vinylarene with Unactivated Aliphatic Substitution
收藏NIAID Data Ecosystem2026-03-11 收录
数据链接：
官方服务：
资源简介：
Oxidative coupling is a useful tool to synthesize vinylarenes. Despite remarkable successes in linear vinylarene, branched vinylarene synthesis has remained underdeveloped. Overcoming this limitation, herein, we report a chelation-assisted oxidative coupling to generate branched olefinated product in high yield. Exclusive branched selectivity was obtained using alkenyl carboxylic acid. Detailed experimental studies combined with computational investigations suggest that β-migratory insertion, followed by a decarboxylation pathway is operative for the overall transformation.
创建时间：
2019-09-09
