Allo litocholic acid, a microbiome derived secondary bile acid, attenuates liver fibrosis

Bile acids (BAs) are amphipatic molecules synthesized in the liver. Beside their role in nutrient absorption, BAs act as signaling molecules exerting a variety of regulatory function by activating a family of receptors called “bile acid-regulated receptors” (BARRs). From primary bile acid, these molecules undergo extensive microbial modifications in the intestine, generating secondary bile acids such as deoxycholic acid (DCA), lithocholic acid (LCA), and derivatives, including allo-LCA. Recent studies have shown that these bile acids can act simultaneously as GPBAR1 agonist and as RORγt inverse agonist. The aim of the study was to evaluate the effect of the administration of Allo-LCA, in preventing the development of MASH