Dynamic upregulation of retinoic acid RA signal in the early postnatal murine heart promotes cardiomyocyte cell cycle exit and maturation

Retinoic acid (RA), the major active metabolite of vitamin A, is essential for organogenesis, homeostasis, and tissue morphogenesis. Despite the importance of RA signaling in embryo heart development, little is known about its function in the early postnatal period. To analyze the function of RA signaling during perinatal heart development, we investigated the mRNA expression levels of multiple retinoid metabolic genes at various perinatal stages using RNA-seq analysis.视黄酸（Retinoic acid, RA）是维生素A的主要活性代谢产物，在器官发生、体内稳态以及组织形态发生过程中不可或缺。尽管视黄酸信号通路在胚胎心脏发育中具有重要作用，但目前学界对其在出生后早期阶段的功能仍所知有限。为解析视黄酸信号通路在围产期心脏发育中的功能，本研究采用RNA测序（RNA-seq）分析技术，检测了不同围产期阶段下多种类视黄醇代谢基因的mRNA表达水平。