Additional file 6 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

Additional file 5 Gene lists and GO enrichment analyses for Pxr-/- vs Pxr+/+ transcriptome comparisons. (A) List of genes significantly up-regulated in males Pxr-/- compared to males Pxr+/+. (B) GO term enrichment analysis using the list of genes significantly up-regulated in males Pxr-/- compared to males Pxr+/+. Metabolic pathways (summary) were considered as significantly enriched when q-value < 0.05. (C) List of genes significantly up-regulated in females Pxr-/- compared to females Pxr+/+. (D) GO term enrichment analysis using the list of genes significantly up-regulated in females Pxr-/- compared to females Pxr+/+. Metabolic pathways (summary) were considered as significantly enriched when q-value < 0.05. (E) List of genes significantly down-regulated in males Pxr-/- compared to males Pxr+/+. (F) GO term enrichment analysis using the list of genes significantly up-regulated in males Pxr-/- compared to males Pxr+/+. No summary metabolic pathways (summary) were considered as significantly enriched with q-value < 0.05. (A) List of genes significantly down-regulated in females Pxr-/- compared to females Pxr+/+. (B) GO term enrichment analysis using the list of genes significantly down-regulated in females Pxr-/- compared to females Pxr+/+. Metabolic pathways (summary) were considered as significantly enriched when q-value < 0.05.