Mass spectrometry of HLA-I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation

Data from ProteomeXchange, PXD ID: PXD000394. Cell type: Fib_1, file: 20130517_EXQ3_MiBa_SA_Fib_1_scx1.mzml. Published as part of . From the Abstract: {{i}} ... Here we present a high-throughput mass spectrometry based workflow that allows stringent and accurate identification of thousands of such peptides and direct determination of binding motifs. Applying the workflow to seven cancer cell lines and primary cells, yielded more than 22,000 unique HLA peptides across different allelic binding specificities ... {{/i}}