Collective Synthesis and PCSK9 Inhibitory Activities of Pavine and Isopavine Alkaloids
收藏NIAID Data Ecosystem2026-05-02 收录
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https://figshare.com/articles/dataset/Collective_Synthesis_and_PCSK9_Inhibitory_Activities_of_Pavine_and_Isopavine_Alkaloids/29465224
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资源简介：
An efficient approach for the synthesis of pavine and
isopavine
alkaloids through photoredox-catalyzed intramolecular cyclization
is disclosed, which features low catalyst dosage and good functional
group compatibility. A total of 18 natural products, including 10
pavine and 8 isopavine alkaloids as well as 20 analogs, have been
successfully synthesized by this protocol. A plausible reaction mechanism
was also proposed. Moreover, preliminary PCSK9 inhibitory activities
of these compounds were evaluated. Compound 1’f exhibited the most potent PCSK9 inhibitory activity with the IC50 value of 161 nM, superior to the positive control berberine.
创建时间：
2025-07-02
