Adult T-cells impair neonatal cardiac regeneration

Neonate mice and men display a transient cardiac regenerative potential that rapidly declines postnatally. Thus, patients that survive a myocardial infarction (MI) often develop chronic heart failure (HF) as a consequence of this poor myocardial healing capacity. Herein, we hypothesized that the cardiac “regenerative-to-scarring” transition is driven by the developing adaptive immune system. mRNA profile of neonatal hearts from control and adult T-transferred mice