Quantification of YFP marked insulin+ cells in CAII-CreERTM:R26R-eYFP (bigenic) mice 18 days after chronic Fc-TWEAK or control Ig treatment.

All animals were bigenic CAII-CreERTM:R26-eYFP mice. Control mice had no TM or drug (control Ig or Fc-TWEAK) treatment. For each animal, all insulin positive cells on a single full footprint pancreatic section were examined for co-expression with eYFP in islets or in aggregates (defined as being 8 cells or less in cross section). Mean values ±SEM are reported, and the last two columns report individual values/animal.