TLR4 in Breast Cancer

Breast cancer (BC) is heterogeneous in clinical manifestation, of which the triple negative (TNBC) subtype is the most aggressive. This study examines the associations between Toll-Like Receptor (TLR)-4 polymorphisms and the susceptibility to BC and TNBC. Genotyping of TLR-4 rs2770150, rs2149356, rs1554973 and rs7856729 polymorphisms was done by real-time PCR in 488 women with BC (130 TNBC, 358 non-TNBC), and 476 cancer-free control women.