Supporting data for "DriverMP enables improved identification of cancer driver genes"

Cancer is widely regarded as a complex disease primarily driven by genetic mutations. A critical concern and significant obstacle lies in discerning driver genes amidst an extensive array of passenger genes. <br>We present a new method termed DriverMP for effectively prioritizing altered genes on a cancer-type level by considering mutated gene pairs. It is designed to first apply non-silent somatic mutation data, proteinprotein interaction network data, and differential gene expression data to prioritize mutated gene pairs, and then individual mutated genes are prioritized based on prioritized mutated gene pairs. Application of this method in ten TCGA cancer datasets demonstrated its great improvements over all the compared state-of-the-art methods in identifying known driver genes. Then, a comprehensive analysis demonstrated the reliability of the novel driver genes that are strongly supported by clinical experiments, disease enrichment, or biological pathway analysis. <br>The new method, DriverMP, is able to identify driver genes by effectively integrating the advantages of multiple kinds of cancer data, which is available at https://github.com/LiuYangyangSDU/DriverMP. In addition, we have developed a novel driver gene database (available at http://www.liulab.top/DriverMP/table) for ten cancer types and an online service that can be freely accessed without registration for users (available at http://liulab.top/DriverMP/server). The DriverMP method, the database of novel drivers, and the user-friendly online server are expected to contribute to new diagnostic and therapeutic opportunities for cancers.