MAP kinase p38 phosphorylates KSRP

Activated MAPK p38 alpha and beta phosphorylate KSRP at threonine692. The phosphorylation interferes with the ability of KSRP to bind and destabilize RNA. Thus RNAs become stabilized.

活化的 MAPK p38 酪氨酸激酶 α 和 β 亚型特异性磷酸化 KSRP 蛋白在丝氨酸 692 位点。该磷酸化作用干扰了 KSRP 与 RNA 结合并使其不稳定的活性，进而导致 RNA 的稳定性增加。