Spleen glia are a transcriptionally unique glial subtype interposed between immune cells and sympathetic axons

Non-myelinating glia in visceral organs have not been well characterized. It Is likely they have unique functions in the organs in which they reside. This is interesting in immune organs such as the spleen in which glia ensheath nerves that come in close contact with immune cells. However, glia in the spleen have not been well characterized. We report here an in-depth anatomical and transcriptional characterization of spleen glia. Examination of spleen glia enriched genes compared to whole spleen内脏器官中的非髓鞘胶质细胞（non-myelinating glia）目前尚未得到充分的特征解析。它们大概率在所栖息的器官中发挥独特的功能。这一点在脾脏等免疫器官中尤为值得关注：脾脏内的胶质细胞会包裹与免疫细胞紧密接触的神经纤维。然而，脾脏内的胶质细胞同样尚未得到充分的特征解析。本研究对脾脏胶质细胞开展了深入的解剖学与转录组学特征解析。相较于全脾脏组织，对脾脏胶质细胞富集基因的分析