Identification of a nonneuronal isoform of synaptotagmin.
收藏PubMed Central1995-06-20 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC41608/
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资源简介：
Synaptotagmins, which have been found exclusively in neuroendocrine or exocrine tissues, have been implicated in the regulation of secretory vesicle fusion with the plasma membrane. The present paper describes a synaptotagmin isoform (synaptotagmin-5) which exhibits 49% amino acid identity to synaptotagmin-1 and -2. Synaptotagmin-5 mRNA is expressed in rat kidney, adipose tissue, lung, and heart, as well as at higher levels in brain and PC12 cells. Antiserum specific for the synaptotagmin-5 isoform recognizes a protein of about 50 kDa which is about 6-fold more abundant in brain synaptic vesicles than in whole brain membranes. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1995-06-20
