Transcriptomic profiling of mouse cerebral cortex following chronic exposure to polystyrene nanoplastics

This study investigates the transcriptomic alterations in the cerebral cortex of C57BL/6 mice following chronic oral exposure to environmentally relevant polystyrene nanoplastics (100 nm and 500 nm). RNA sequencing was performed to assess differential gene expression associated with microglial activation, neuroinflammation, and purinergic signaling pathways.