Couple transcriptome and genomic data obtained from the PDXs to identify pathways linking oncogenic alterations. Couple transcriptome and genomic data obtained from the PDXs to identify pathways linking oncogenic alterations

Purpose: Study the changes in cell transcriptome in breast cancer with respect to normal breast tissue in association with somatic mutations Methods: RNA was extracted from frozen normal breast tissues and PDXs cells Results: We found over-expression of oncogenic pathways associated with oncogenic mutations in PDXs Overall design: Analysis of differential gene expression in metastatic breast cancer PDXs