Research progress on the correlation between hyperglycemia and colorectal cancer

Hyperglycemic status is associated with the development and prognosis of colorectal cancer (CRC), although the exact mechanisms are not fully understood. Hyperglycemia can promote the development of CRC through affecting cell proliferation and apoptosis mechanisms, inflammatory responses, oxidative stress, immunomodulation, angiogenesis, and other pathways. In terms of prognosis, hyperglycemia may affect the survival and recurrence rates of CRC patients as well as chemotherapy resistance, but the results of related studies are not yet consistent. The hypoglycemic treatment may have a positive impact on the prognosis of CRC patients, but the specific effects need further research. Therefore, this article systematically explores the relationship between hyperglycemia and CRC, analyzes the impact of hyperglycemia on the occurrence and prognosis of CRC, and discusses the role of managing and intervening hyperglycemia in CRC.