Prion infectivity of olfactory bulb and olfactory mucosa lysates following HY TME inoculation.

aFollowing inoculation by either route, olfactory bulb and mucosa were collected from hamsters with HY TME, lysates prepared, and 25 µg protein lysate was i.c. inoculated into each recipient hamster (N = 4) in the animal bioassay.
bInfectivity titers were estimated using the incubation interval assay [29], [32], [33].
cTotal median lethal doses were calculated by multiplying the HY TME LD50 per µg protein by the total amount of protein in each lysate.
d, ep-value<0.001 between olfactory bulb and olfactory mucosa from individual hamster, Tukey-Kramer pair-wise analysis.