Age-associated difference between young-adult and aged ferrets during SFTSV infection

This longitudinal scRNA-seq analysis examines age-related differences, focusing particularly on the B cell response, between young-adult and aged ferrets during SFTSV infection. To elucidate age-dependent SFTSV progression, we performed longitudinal single-cell RNA sequencing (scRNA-seq) on the spleen, PBMC, and BM of young-adult and aged ferrets—an established immunocompetent animal model reflecting fatal clinical symptoms of human SFTSV infections. Our analysis revealed distinct age-related differences in immune response