Two new mixed-ligand coordination polymers: structural characterization and treatment effect on acute adnexitis via inhibiting <i>fitZ</i> gene expression in <i>Staphylococcus aureus</i>
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Two new mixed-ligand coordination polymers with the chemical formulae of {[Zn<sub>3</sub>(nbta)<sub>2</sub>(bpfp)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](H<sub>2</sub>O)<sub>2</sub>}<sub>n</sub> (<b>1</b>, H<sub>3</sub>nbta = 5-nitro-1,2,3-benzenetricarboxylic acid, bpfp = bis(4-pyridylformyl)piperazine) and {[Cd<sub>3</sub>(nbta)<sub>1.5</sub>(bib)<sub>2</sub>(H<sub>2</sub>O)](H<sub>2</sub>O)}<sub>n</sub> (<b>2</b>, bib= 4,4’-bis((1H-imidazol-1-yl)methyl)−1,1’-biphenyl) have been successfully synthesized by the solvothermal reaction of 5-nitro-1,2,3-benzenetricarboxylic acid, and different N-donor co-ligand. All compounds were adequately characterized, and their structures were verified by single-crystal X-ray diffraction along with the elemental analysis. Furthermore, the treatment effect of compounds <b>1</b> and <b>2</b> on the acute adnexitis was evaluated in the biological study. Firstly, the RT-PCR was performed to detect the inhibitory effect of the compounds on the survival gene in the <i>Staphylococcus aureus-fitZ</i>. Then, the ELISA was conducted to measure the release level of the inflammatory cytokines.
