Increased spatial coupling of integrin and collagen IV in the immunoresistant clear-cell renal-cell carcinoma tumor microenvironment - Validation mIF

mIF object from spatialTIME R package, calculating univariate Ripley's K on multiplex immunofluorescence images stained with FOXP3, CD8, CD68, ITGAV, COL4, VIM, SMA, and PCK. Data was processed with InForm and HALO. 

Clear cell renal cell carcinoma and papillary renal cell carcinoma were profiled before and after exposure to immunotherapy, with and without sarcomatoid features in clear cell tumors. Each tumor had a field of view in the stromal compartment and field of view in the tumor compartment.

For appropriate clinical information associated with this study, please contact Dr. Brandon Manley.