RNASeq_of_mouse_DDD_models_Y4

We are continuing our QQ work to identify the molecular underpinnings of human developmental disorders identified in the DDD project. To do this, we are carrying out RNA sequencing in mouse models of disease, particularly those affecting chromatin modifying proteins. We are performing RNAseq on adult brain sub-regions known to be important in learning and memory. We are also performing RNAseq on brain tissue from foetal timepoints, to examine the impact of these mutations on prenatal eurodevelopment. This will allow us to distinguish early effects in neurodevelopment and late effects on normal brain function, identifying critical timepoints in these disorders and the transcriptional changes underlying these disorders.