Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel

To investigate the timing of endogenous regenerative events in response to a single 10 Gy dose of IR, we sequeced the transcriptomes of glands from adult (6-7 wks)mice and 7- and 14-days post-IR. We then compared to the radiated glands to Non-IR (no radiation) controls, and performed differential expression analysis. Overall design: Comparative gene expression profiling analysis of RNA-seq data for Ct (Non-IR, no radiation control), IR7 (7 days post-radiation) and IR14 (14 days post-radiation) sublingual salivary glands.