Genomic epidemiology of the BC002 M. tuberculosis cluster

We sequenced 64 M. tuberculosis genomes as part of an investigation into the BC002 cluster, a group of cases with identical 24-loci MIRU-VNTR genotypes. 48 of the 64 genomes are from isolates epidemiologically linked to an outbreak originating in one region of British Columbia, while the remaining isolates are from cases not epidemiologically linked to the outbreak and located in another region. Genomes K01-K40 were sequenced to extremely high coverage on the HiSeq; genomes K41-K64 were sequenced on a MiSeq. All isolates sequenced come from individual patients except K07 and K08, which were taken from the same patient approximately five months apart.