Difluoro-Substituted Bicyclo[1.1.1]pentanes for Medicinal Chemistry: Design, Synthesis, and Characterization
收藏Figshare2019-09-25 更新2026-04-29 收录
下载链接：
https://figshare.com/articles/dataset/Difluoro-Substituted_Bicyclo_1_1_1_pentanes_for_Medicinal_Chemistry_Design_Synthesis_and_Characterization/9941852
下载链接
链接失效反馈官方服务：
资源简介：
A practical synthetic approach to the difluoro-substituted bicyclo[1.1.1]pentanes was developed. The key step was an addition of difluorocarbene (:CF2) to electron-rich bicyclo[1.1.0]butanes by the CF3TMS/NaI system. The obtained difluoro-bicyclo[1.1.1]pentanes are suggested to be used as saturated bioisosteres of benzene rings for the purpose of drug discovery projects.
创建时间：
2019-09-25
