Carbapenem-Resistant Klebsiella pneumoniae

Carbapenem-resistant K. pneumoniae (CRKP) is the most common CRE, and its prevalence of CRKP increased from 2.9% to 24.2% between 2005 and 2022. The spread of CRKP and its clinical outcomes pose a considerable threat to public health. Between 2016 and 2023, 255 clinical K. pneumoniae strains were isolated from five hospitals in Yangzhou City. 24.31% (62/255) of the strains were identified as CRKP. SNP analysis of the 62 CRKP strains showed that ST11 and ST15 were the predominant types and that the strains showed a clear tendency to cluster by year and location. The percentage of CRKP increased with the passing of the year, from 6.67% in 2016 to 2022 of 51.72% (P < 0.05), and the number of CRKP isolates in 2022-2023 accounted for 45.16% (28/62) of all CRKP.